Hey! I play a warlock and I found this to be very annoying. But I did find a solution, at the top of your map when you press 'M' there should be a toggle Questie button, and just click it twice to refresh Questie. Hope this helps!
I don't use Questie and have the same issue. I just always assumed it was from my action bar addon, but the benefits to me outweighed the slight inconvenience.
Usually when I need to reload I put my pet on "stay" run out of range to get my Soul Shard back, then reload while I have no pet. And if you are a Hunter, just dismiss and re-summon it without having to worry about Soul Shards.